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ea0035p781 | Obesity | ECE2014

Hyperleptinemia and insulin resistance in obesity-associated sleep apnoea: Sex-dependent effects of CPAP application

Andrada Patricia , Pascual Eider , Perez Belen , Gutierrez Gala , Pujante Pedro , Silva Camilo , Iriarte Jorge , Escalada Javier , Galofre Juan Carlos , Gomez-Ambrosi Javier , Fruhbeck Gema , Salvador Javier

Obstructive sleep apnoea (OSA) is very common in severe obese patients and has been related to insulin resistance (IR) and hyperleptinemia, and these findings may have effects on food behavior and obesity complications. In order to explore this relationship and the role of sex we have studied 531 patients with morbid obesity (BMI 42.8+6.5 kg/m2). A full polysomnographic study and glucose, insulin and leptin measurements as well as air displacement plethysmography we...

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ea0032p755 | Obesity | ECE2013

Apnoeic episodes impair insulin resistance independently of oxygen desaturations: evidence from morbid obese patients with discordant apnoea/desaturation indexes

Andrada Patricia , Chacon Ana , Pascual Eider , Silva Camilo , Iriarte Jorge , Gil Maria J , Pujante Pedro , Abreu Cristina , Escalada Javier , Fruhbeck Gema , Salvador Javier

Morbid obesity (MO) is often complicated by obstructive sleep apnoea (OSA), which in some cases is evaluated by pulsioximetry. This cross-sectional study was designed to investigate the prevalence of discordance between desaturation index (DI) and apnoeahypopnoea index (AHI) and its effects on insulin resistance and secretion in MO patients candidate to bariatric surgery (n=496) in whom a full polysomnographic study was carried out. We identified 163 (33%) out o...

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Endocrine Abstracts

Hyperleptinemia and insulin resistance in obesity-associated sleep apnoea: Sex-dependent effects of CPAP application

Apnoeic episodes impair insulin resistance independently of oxygen desaturations: evidence from morbid obese patients with discordant apnoea/desaturation indexes

BiosciAbstracts